Histopathological and molecular analysis in dermis and epidermis of patients with systemic and localized scleroderma
نویسندگان
چکیده
Methods Single-blind clinical trial. The tissue samples obtained from patients PAS, hematoxylin and eosin, E-Cadherin, CTGF, Tunnel, and staining for TGF-b1 is applied and evaluated by light microscopy. Additionally, we have analyzed both TGFB1 level and mRNA expression analysis in plasma and tissue samples from patients. A total of 15 patients were enrolled in the study. These patients, who were chosen from, systemic (n = 8) or localized (n = 7) scleroderma patients clinically received, and for the disease of any systemic untreated and scleroderma other than skin disease.
منابع مشابه
Age, sex and type distribution of localized Scleroderma in patients referred to Boo-Ali Hospital in Tehran, 1995-99
Background: There is no data on the characteristics of patients with localized scleroderma in Iran. Objective: In order to determine the age, sex and type distribution of localized scleroderma in Iran, this study was done on patients referred to Boo-Ali Hospital in Tehran in 1995-1999. Patients and Methods: This study was done as an existing data study on 39 patients with localized scleroderma ...
متن کاملHistopathological and clinical traps in lichen sclerosus: a case report.
Lichen sclerosus et atrophicus and limited systemic scleroderma (acrosclerosis) are inflammatory skin diseases that ultimately evolve into two distinct modes of atrophic scar formation, but which can easily be confused clinically. They are very rarely associated. The literature has reported cases in which lichen sclerosus was associated with various forms of scleroderma, but often with localize...
متن کاملFrictional melanosis and its clinical and histopathological features
Background: A rippled type of pigmentation is observed on the arms, forearms, and bony prominences, more commonly in women with a history of chronic rubbing. The terminology (commonly referred to as frictional melanosis) and its relation with cutaneous amyloidosis has been debated. Materials and Methods: Twenty one patients with pigmented skin lesions with manifestations suggestive of frictiona...
متن کاملPeriostin in Mature Stage Localized Scleroderma
BACKGROUND Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in localized scleroderma are rare. OBJECTIVE To investigate the expression of periostin and other molecules in localized scleroderma. METHODS A retrospective study of 14 pati...
متن کاملHistometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis
BACKGROUND It would be a benefit if time-saving, non-invasive methods could give hints for diagnosing systemic sclerosis. To investigate the skin of patients with systemic sclerosis using confocal laser scanning microscopy in vivo and to develop histometric parameters to describe characteristic cutaneous changes of systemic sclerosis observed by this new technique, we conducted an exploratory s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2014